Breast Cancer Articles page 9

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). For more details read out the article:

GPR83 is a member of the Orphan-A G-Protein coupled receptor family, and has anunknown ligand. It has been previously reported in various regions of the brain, within a subset of T-lymphocytes, and by RT-PCR at low levels in heart, kidney, liver, and otherorgans. For more details read out the article:

NF-kB (Nuclear Factor-KappaB) is a heterodimeric protein composed of different combinations of members of the Rel family of transcription factors. The Rel/NF-kB family of transcription factors are involved mainly in stress-induced, immune, and inflammatory responses. For more details read out the article:

IMGENEX History-Array tissue array slides are a simple, powerful, inexpensive, yet highly efficient method for expression analysis or localization studies of molecular targets at the DNA, RNA or protein level. For more details read out the article:

As one of the largest and most diverse protein families in nature, the G-protein coupled receptor (GPCR) superfamily play important roles in a variety of biological and pathological processes such as development and proliferation, neuromodulation, angiogenesis, metabolic disorders, inflammation, Not surprisingly, it is one of the most targeted protein families in pharmaceutical research today(Schlyer 2006).To find out the recent findings by IMGENEX, read the following articl

The principle of the ChIP assay is simple yet the process can be technically challenging. It is with these challenges in mind that IMGENEX developed the QuikChIP Kit for chromatin immunoprecipitation. Find out more information from the following article:

IMGENEX offers over 90 Chromatin, DNA Methylation & Repair, and DNA Fragmentation-related antibodies, many of which have been cited in numerous peer-reviewed journals. Find out more details in the following article:

All the cellular processes in living cells such as growth, development, morphogenesis and cellular differentiation are a product of gene expression programs involving complicated transcriptional regulation of several genes. This process of transcriptional regulation is tightly controlled and coordinated by proteins called transcriptional regulators.

Toll-like Receptor (TLR) family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs are evolutionarily conserved and their congeners have been found in insects, plants, and mammals. For more details read out the following article:

Early development and differentiation of nascent T cells inside the thymus is a complex and remarkable mechanism. Around 1010 TCR variations are generated in developing lymphocyte clones through a random process of somatic cell gene reorganization. These types of T-cells require a different strategy to tame their autoimmune potential. One of many immunotolerance mechanisms that immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. For more